An Immunosurveillance Mechanism Controls Cancer Cell Ploidy
Identifieur interne : 005E76 ( Main/Exploration ); précédent : 005E75; suivant : 005E77An Immunosurveillance Mechanism Controls Cancer Cell Ploidy
Auteurs : Laura Senovilla [France] ; Ilio Vitale [France] ; Isabelle Martins [France] ; Maximilien Tailler [France] ; Claire Pailleret [France] ; Mickaël Michaud [France] ; Lorenzo Galluzzi [France] ; Sandy Adjemian [France] ; Oliver Kepp [France] ; Mireia Niso-Santano [France] ; Shensi Shen [France] ; Guillermo Marino [France] ; Alfredo Criollo [France] ; Alice Boileve [France] ; Bastien Job [France] ; Sylvain Ladoire [France] ; François Ghiringhelli [France] ; Antonella Sistigu [France] ; Takahiro Yamazaki [France] ; Santiago Rello-Varona [France] ; Clara Locher [France] ; Vichnou Poirier-Coiame [France] ; Monique Talbot ; Alexander Valent [France] ; Francesco Berardinelli [Italie] ; Antonio Antoccia [Italie] ; Fabiola Ciccosanti [Italie] ; Gian Maria Fimia [Italie] ; Mauro Piacentini [Italie] ; Antonio Fueyo [Espagne] ; Nicole L. Messina [Australie] ; MING LI [Australie] ; Christopher J. Chan [Australie] ; Verena Sigl [Autriche] ; Guillaume Pourcher [France] ; Christoph Ruckenstuhl [Autriche] ; Didac Carmona-Gutierrez [Autriche] ; Vladimir Lazar [France] ; Josef M. Penninger [Autriche] ; Frank Madeo [Autriche] ; Carlos Lopez-Otin [Espagne] ; Mark J. Smyth [Australie] ; Laurence Zitvogel [France] ; Maria Castedo ; Guido Kroemer [France]Source :
- Science : (Washington, D.C.) [ 0036-8075 ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Cancer.
English descriptors
- KwdEn :
Abstract
Cancer cells accommodate multiple genetic and epigenetic alterations that initially activate intrinsic (cell-autonomous) and extrinsic (immune-mediated) oncosuppressive mechanisms. Only once these barriers to oncogenesis have been overcome can malignant growth proceed unrestrained. Tetraploidization can contribute to oncogenesis because hyperploid cells are genomically unstable. We report that hyperploid cancer cells become immunogenic because of a constitutive endoplasmic reticulum stress response resulting in the aberrant cell surface exposure of calreticulin. Hyperploid, calreticulin-exposing cancer cells readily proliferated in immunodeficient mice and conserved their increased DNA content. In contrast, hyperploid cells injected into immunocompetent mice generated tumors only after a delay, and such tumors exhibited reduced DNA content, endoplasmic reticulum stress, and calreticulin exposure. Our results unveil an immunosurveillance system that imposes immunoselection against hyperploidy in carcinogen- and oncogene-induced cancers.
Affiliations:
- Australie, Autriche, Espagne, France, Italie
- Bourgogne, Bourgogne-Franche-Comté, Latium, Victoria (État), Vienne (Autriche), Île-de-France
- Dijon, Melbourne, Paris, Rome, Vienne (Autriche)
- Université de Melbourne
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aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Marino, Guillermo" sort="Marino, Guillermo" uniqKey="Marino G" first="Guillermo" 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Génomique Fonctionnelle et Bioinformatique</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Genomique Platform</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>15 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Genomique Platform</wicri:noRegion><wicri:noRegion>Genomique Platform</wicri:noRegion></affiliation></author><author><name sortKey="Ladoire, Sylvain" sort="Ladoire, Sylvain" uniqKey="Ladoire S" first="Sylvain" last="Ladoire">Sylvain Ladoire</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Medical Oncology, Georges François Leclerc Center</s1><s2>Dijon</s2><s3>FRA</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Institut National de la Sante et de la Recherche Médicale, Avenir Team INSERM, CRI-866 University of Burgundy</s1><s2>Dijon</s2><s3>FRA</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Ghiringhelli, Francois" sort="Ghiringhelli, Francois" uniqKey="Ghiringhelli F" first="François" last="Ghiringhelli">François Ghiringhelli</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Medical Oncology, Georges François Leclerc Center</s1><s2>Dijon</s2><s3>FRA</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Institut National de la Sante et de la Recherche Médicale, Avenir Team INSERM, CRI-866 University of Burgundy</s1><s2>Dijon</s2><s3>FRA</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Sistigu, Antonella" sort="Sistigu, Antonella" uniqKey="Sistigu A" first="Antonella" last="Sistigu">Antonella Sistigu</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>INSERM, U1015</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>43 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>U1015</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Yamazaki, Takahiro" sort="Yamazaki, Takahiro" uniqKey="Yamazaki T" first="Takahiro" last="Yamazaki">Takahiro Yamazaki</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>INSERM, U1015</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>43 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>U1015</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Rello Varona, Santiago" sort="Rello Varona, Santiago" uniqKey="Rello Varona S" first="Santiago" last="Rello-Varona">Santiago Rello-Varona</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U848</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>U848</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Locher, Clara" sort="Locher, Clara" uniqKey="Locher C" first="Clara" last="Locher">Clara Locher</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>INSERM, U1015</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>43 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>U1015</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Poirier Coiame, Vichnou" sort="Poirier Coiame, Vichnou" uniqKey="Poirier Coiame V" first="Vichnou" last="Poirier-Coiame">Vichnou Poirier-Coiame</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>INSERM, U1015</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>43 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>U1015</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Talbot, Monique" sort="Talbot, Monique" uniqKey="Talbot M" first="Monique" last="Talbot">Monique Talbot</name></author><author><name sortKey="Valent, Alexander" sort="Valent, Alexander" uniqKey="Valent A" first="Alexander" last="Valent">Alexander Valent</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Pathologie Moléculaire, Departement De Biologie et Pathologie Médicales</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>24 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Departement De Biologie et Pathologie Médicales</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Berardinelli, Francesco" sort="Berardinelli, Francesco" uniqKey="Berardinelli F" first="Francesco" last="Berardinelli">Francesco Berardinelli</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Dipartimento Di Biologia, Università Roma Tre</s1><s2>Rome</s2><s3>ITA</s3><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Antoccia, Antonio" sort="Antoccia, Antonio" uniqKey="Antoccia A" first="Antonio" last="Antoccia">Antonio Antoccia</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Dipartimento Di Biologia, Università Roma Tre</s1><s2>Rome</s2><s3>ITA</s3><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Ciccosanti, Fabiola" sort="Ciccosanti, Fabiola" uniqKey="Ciccosanti F" first="Fabiola" last="Ciccosanti">Fabiola Ciccosanti</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>National Institute for Infectious Diseases L. Spallanzani</s1><s2>Rome</s2><s3>ITA</s3><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Fimia, Gian Maria" sort="Fimia, Gian Maria" uniqKey="Fimia G" first="Gian Maria" last="Fimia">Gian Maria Fimia</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>National Institute for Infectious Diseases L. Spallanzani</s1><s2>Rome</s2><s3>ITA</s3><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Piacentini, Mauro" sort="Piacentini, Mauro" uniqKey="Piacentini M" first="Mauro" last="Piacentini">Mauro Piacentini</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>National Institute for Infectious Diseases L. Spallanzani</s1><s2>Rome</s2><s3>ITA</s3><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Department of Biology, University of Rome "Tor Vergata</s1><s2>Rome</s2><s3>ITA</s3><sZ>29 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Fueyo, Antonio" sort="Fueyo, Antonio" uniqKey="Fueyo A" first="Antonio" last="Fueyo">Antonio Fueyo</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Departamento de Biología Funcional, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo</s1><s2>Oviedo</s2><s3>ESP</s3><sZ>30 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Messina, Nicole L" sort="Messina, Nicole L" uniqKey="Messina N" first="Nicole L." last="Messina">Nicole L. Messina</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne</s1><s2>Victoria</s2><s3>AUS</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="15"><s1>Sir Peter MacCallum Department of Oncology, University of Melbourne</s1><s2>Parkville, Victoria</s2><s3>AUS</s3><sZ>31 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Ming Li" sort="Ming Li" uniqKey="Ming Li" last="Ming Li">MING LI</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne</s1><s2>Victoria</s2><s3>AUS</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Christopher J" sort="Chan, Christopher J" uniqKey="Chan C" first="Christopher J." last="Chan">Christopher J. Chan</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne</s1><s2>Victoria</s2><s3>AUS</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Immunology, Monash University</s1><s2>Prahran, Victoria</s2><s3>AUS</s3><sZ>33 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Prahran, Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Sigl, Verena" sort="Sigl, Verena" uniqKey="Sigl V" first="Verena" last="Sigl">Verena Sigl</name><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA)</s1><s2>Vienna</s2><s3>AUT</s3><sZ>34 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Pourcher, Guillaume" sort="Pourcher, Guillaume" uniqKey="Pourcher G" first="Guillaume" last="Pourcher">Guillaume Pourcher</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Minimal Invasive Surgery, Antoine Béclère Hospital, AP-HP</s1><s2>Clamart</s2><s3>FRA</s3><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Clamart</wicri:noRegion><wicri:noRegion>AP-HP</wicri:noRegion><wicri:noRegion>Clamart</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>INSERM, U972</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>U972</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Ruckenstuhl, Christoph" sort="Ruckenstuhl, Christoph" uniqKey="Ruckenstuhl C" first="Christoph" last="Ruckenstuhl">Christoph Ruckenstuhl</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Institute for Molecular Bioscience</s1><s2>Graz</s2><s3>AUT</s3><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Institute for Molecular Bioscience</wicri:noRegion></affiliation></author><author><name sortKey="Carmona Gutierrez, Didac" sort="Carmona Gutierrez, Didac" uniqKey="Carmona Gutierrez D" first="Didac" last="Carmona-Gutierrez">Didac Carmona-Gutierrez</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Institute for Molecular Bioscience</s1><s2>Graz</s2><s3>AUT</s3><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Institute for Molecular Bioscience</wicri:noRegion></affiliation></author><author><name sortKey="Lazar, Vladimir" sort="Lazar, Vladimir" uniqKey="Lazar V" first="Vladimir" last="Lazar">Vladimir Lazar</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Unité de Génomique Fonctionnelle et Bioinformatique</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>15 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Unité de Génomique Fonctionnelle et Bioinformatique</wicri:noRegion><wicri:noRegion>Unité de Génomique Fonctionnelle et Bioinformatique</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Genomique Platform</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>15 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Genomique Platform</wicri:noRegion><wicri:noRegion>Genomique Platform</wicri:noRegion></affiliation></author><author><name sortKey="Penninger, Josef M" sort="Penninger, Josef M" uniqKey="Penninger J" first="Josef M." last="Penninger">Josef M. Penninger</name><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA)</s1><s2>Vienna</s2><s3>AUT</s3><sZ>34 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Madeo, Frank" sort="Madeo, Frank" uniqKey="Madeo F" first="Frank" last="Madeo">Frank Madeo</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Institute for Molecular Bioscience</s1><s2>Graz</s2><s3>AUT</s3><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Institute for Molecular Bioscience</wicri:noRegion></affiliation></author><author><name sortKey="Lopez Otin, Carlos" sort="Lopez Otin, Carlos" uniqKey="Lopez Otin C" first="Carlos" last="Lopez-Otin">Carlos Lopez-Otin</name><affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Departamento de Bioquimica y Biología Molecular, Facultad de Medicina, IUOPA, Universidad de Oviedo</s1><s2>Oviedo</s2><s3>ESP</s3><sZ>41 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J." last="Smyth">Mark J. Smyth</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne</s1><s2>Victoria</s2><s3>AUS</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Immunology, Monash University</s1><s2>Prahran, Victoria</s2><s3>AUS</s3><sZ>33 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Prahran, Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>INSERM, U1015</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>43 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>U1015</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>43 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507</wicri:noRegion><wicri:noRegion>Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507</wicri:noRegion></affiliation></author><author><name sortKey="Castedo, Maria" sort="Castedo, Maria" uniqKey="Castedo M" first="Maria" last="Castedo">Maria Castedo</name></author><author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Metabolomics Platform, Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>45 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="24"><s1>Centre de Recherche des Cordeliers</s1><s2>Paris</s2><s3>FRA</s3><sZ>45 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Pôle de Biologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris (AP-HP)</s1><s2>Paris</s2><s3>FRA</s3><sZ>45 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0427154</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0427154 INIST</idno><idno type="RBID">Pascal:12-0427154</idno><idno type="wicri:Area/PascalFrancis/Corpus">000F00</idno><idno type="wicri:Area/PascalFrancis/Curation">005021</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001369</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001369</idno><idno type="wicri:doubleKey">0036-8075:2012:Senovilla L:an:immunosurveillance:mechanism</idno><idno type="wicri:Area/Main/Merge">006204</idno><idno type="wicri:Area/Main/Curation">005E76</idno><idno type="wicri:Area/Main/Exploration">005E76</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">An Immunosurveillance Mechanism Controls Cancer Cell Ploidy</title><author><name sortKey="Senovilla, Laura" sort="Senovilla, Laura" uniqKey="Senovilla L" first="Laura" last="Senovilla">Laura Senovilla</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U848</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>U848</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Vitale, Ilio" sort="Vitale, Ilio" uniqKey="Vitale I" first="Ilio" last="Vitale">Ilio Vitale</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U848</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>U848</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Martins, Isabelle" sort="Martins, Isabelle" uniqKey="Martins I" first="Isabelle" last="Martins">Isabelle Martins</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U848</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>U848</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Tailler, Maximilien" sort="Tailler, Maximilien" uniqKey="Tailler M" first="Maximilien" 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aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Pailleret, Claire" sort="Pailleret, Claire" uniqKey="Pailleret C" first="Claire" 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aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Michaud, Mickael" sort="Michaud, Mickael" uniqKey="Michaud M" first="Mickaël" 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aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" 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aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Adjemian, Sandy" sort="Adjemian, Sandy" uniqKey="Adjemian S" first="Sandy" 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aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Kepp, Oliver" sort="Kepp, Oliver" uniqKey="Kepp O" first="Oliver" last="Kepp">Oliver 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aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Marino, Guillermo" sort="Marino, Guillermo" uniqKey="Marino G" first="Guillermo" 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aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Criollo, Alfredo" sort="Criollo, Alfredo" uniqKey="Criollo A" first="Alfredo" 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aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Boileve, Alice" sort="Boileve, Alice" uniqKey="Boileve A" first="Alice" last="Boileve">Alice Boileve</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U848</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>U848</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Job, Bastien" sort="Job, Bastien" uniqKey="Job B" first="Bastien" last="Job">Bastien Job</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Unité de Génomique Fonctionnelle et Bioinformatique</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>15 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Unité de Génomique Fonctionnelle et Bioinformatique</wicri:noRegion><wicri:noRegion>Unité de Génomique Fonctionnelle et Bioinformatique</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Genomique Platform</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>15 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Genomique Platform</wicri:noRegion><wicri:noRegion>Genomique Platform</wicri:noRegion></affiliation></author><author><name sortKey="Ladoire, Sylvain" sort="Ladoire, Sylvain" uniqKey="Ladoire S" first="Sylvain" last="Ladoire">Sylvain Ladoire</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Medical Oncology, Georges François Leclerc Center</s1><s2>Dijon</s2><s3>FRA</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Institut National de la Sante et de la Recherche Médicale, Avenir Team INSERM, CRI-866 University of Burgundy</s1><s2>Dijon</s2><s3>FRA</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Ghiringhelli, Francois" sort="Ghiringhelli, Francois" uniqKey="Ghiringhelli F" first="François" last="Ghiringhelli">François Ghiringhelli</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Medical Oncology, Georges François Leclerc Center</s1><s2>Dijon</s2><s3>FRA</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Institut National de la Sante et de la Recherche Médicale, Avenir Team INSERM, CRI-866 University of Burgundy</s1><s2>Dijon</s2><s3>FRA</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Sistigu, Antonella" sort="Sistigu, Antonella" uniqKey="Sistigu A" first="Antonella" last="Sistigu">Antonella Sistigu</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>INSERM, U1015</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>43 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>U1015</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Yamazaki, Takahiro" sort="Yamazaki, Takahiro" uniqKey="Yamazaki T" first="Takahiro" last="Yamazaki">Takahiro Yamazaki</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave 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aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>U1015</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Rello Varona, Santiago" sort="Rello Varona, Santiago" uniqKey="Rello Varona S" first="Santiago" last="Rello-Varona">Santiago Rello-Varona</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U848</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>U848</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Locher, Clara" sort="Locher, Clara" uniqKey="Locher C" first="Clara" last="Locher">Clara Locher</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>INSERM, U1015</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>43 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>U1015</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Poirier Coiame, Vichnou" sort="Poirier Coiame, Vichnou" uniqKey="Poirier Coiame V" first="Vichnou" last="Poirier-Coiame">Vichnou Poirier-Coiame</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>INSERM, U1015</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>43 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>U1015</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Talbot, Monique" sort="Talbot, Monique" uniqKey="Talbot M" first="Monique" last="Talbot">Monique Talbot</name></author><author><name sortKey="Valent, Alexander" sort="Valent, Alexander" uniqKey="Valent A" first="Alexander" last="Valent">Alexander Valent</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Pathologie Moléculaire, Departement De Biologie et Pathologie Médicales</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>24 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Departement De Biologie et Pathologie Médicales</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Berardinelli, Francesco" sort="Berardinelli, Francesco" uniqKey="Berardinelli F" first="Francesco" last="Berardinelli">Francesco Berardinelli</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Dipartimento Di Biologia, Università Roma Tre</s1><s2>Rome</s2><s3>ITA</s3><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Antoccia, Antonio" sort="Antoccia, Antonio" uniqKey="Antoccia A" first="Antonio" last="Antoccia">Antonio Antoccia</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Dipartimento Di Biologia, Università Roma Tre</s1><s2>Rome</s2><s3>ITA</s3><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Ciccosanti, Fabiola" sort="Ciccosanti, Fabiola" uniqKey="Ciccosanti F" first="Fabiola" last="Ciccosanti">Fabiola Ciccosanti</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>National Institute for Infectious Diseases L. Spallanzani</s1><s2>Rome</s2><s3>ITA</s3><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Fimia, Gian Maria" sort="Fimia, Gian Maria" uniqKey="Fimia G" first="Gian Maria" last="Fimia">Gian Maria Fimia</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>National Institute for Infectious Diseases L. Spallanzani</s1><s2>Rome</s2><s3>ITA</s3><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Piacentini, Mauro" sort="Piacentini, Mauro" uniqKey="Piacentini M" first="Mauro" last="Piacentini">Mauro Piacentini</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>National Institute for Infectious Diseases L. Spallanzani</s1><s2>Rome</s2><s3>ITA</s3><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Department of Biology, University of Rome "Tor Vergata</s1><s2>Rome</s2><s3>ITA</s3><sZ>29 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Fueyo, Antonio" sort="Fueyo, Antonio" uniqKey="Fueyo A" first="Antonio" last="Fueyo">Antonio Fueyo</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Departamento de Biología Funcional, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo</s1><s2>Oviedo</s2><s3>ESP</s3><sZ>30 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Messina, Nicole L" sort="Messina, Nicole L" uniqKey="Messina N" first="Nicole L." last="Messina">Nicole L. Messina</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne</s1><s2>Victoria</s2><s3>AUS</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="15"><s1>Sir Peter MacCallum Department of Oncology, University of Melbourne</s1><s2>Parkville, Victoria</s2><s3>AUS</s3><sZ>31 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Ming Li" sort="Ming Li" uniqKey="Ming Li" last="Ming Li">MING LI</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne</s1><s2>Victoria</s2><s3>AUS</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Christopher J" sort="Chan, Christopher J" uniqKey="Chan C" first="Christopher J." last="Chan">Christopher J. Chan</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne</s1><s2>Victoria</s2><s3>AUS</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Immunology, Monash University</s1><s2>Prahran, Victoria</s2><s3>AUS</s3><sZ>33 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Prahran, Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Sigl, Verena" sort="Sigl, Verena" uniqKey="Sigl V" first="Verena" last="Sigl">Verena Sigl</name><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA)</s1><s2>Vienna</s2><s3>AUT</s3><sZ>34 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Pourcher, Guillaume" sort="Pourcher, Guillaume" uniqKey="Pourcher G" first="Guillaume" last="Pourcher">Guillaume Pourcher</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Université Paris Sud/Paris 11, Faculté de Médecine</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Faculté de Médecine</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Minimal Invasive Surgery, Antoine Béclère Hospital, AP-HP</s1><s2>Clamart</s2><s3>FRA</s3><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Clamart</wicri:noRegion><wicri:noRegion>AP-HP</wicri:noRegion><wicri:noRegion>Clamart</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>INSERM, U972</s1><s2>Le Kremlin Bicêtre</s2><s3>FRA</s3><sZ>35 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>U972</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Ruckenstuhl, Christoph" sort="Ruckenstuhl, Christoph" uniqKey="Ruckenstuhl C" first="Christoph" last="Ruckenstuhl">Christoph Ruckenstuhl</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Institute for Molecular Bioscience</s1><s2>Graz</s2><s3>AUT</s3><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Institute for Molecular Bioscience</wicri:noRegion></affiliation></author><author><name sortKey="Carmona Gutierrez, Didac" sort="Carmona Gutierrez, Didac" uniqKey="Carmona Gutierrez D" first="Didac" last="Carmona-Gutierrez">Didac Carmona-Gutierrez</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Institute for Molecular Bioscience</s1><s2>Graz</s2><s3>AUT</s3><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Institute for Molecular Bioscience</wicri:noRegion></affiliation></author><author><name sortKey="Lazar, Vladimir" sort="Lazar, Vladimir" uniqKey="Lazar V" first="Vladimir" last="Lazar">Vladimir Lazar</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Unité de Génomique Fonctionnelle et Bioinformatique</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>15 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Unité de Génomique Fonctionnelle et Bioinformatique</wicri:noRegion><wicri:noRegion>Unité de Génomique Fonctionnelle et Bioinformatique</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Genomique Platform</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>15 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Genomique Platform</wicri:noRegion><wicri:noRegion>Genomique Platform</wicri:noRegion></affiliation></author><author><name sortKey="Penninger, Josef M" sort="Penninger, Josef M" uniqKey="Penninger J" first="Josef M." last="Penninger">Josef M. Penninger</name><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA)</s1><s2>Vienna</s2><s3>AUT</s3><sZ>34 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Madeo, Frank" sort="Madeo, Frank" uniqKey="Madeo F" first="Frank" last="Madeo">Frank Madeo</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Institute for Molecular Bioscience</s1><s2>Graz</s2><s3>AUT</s3><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Institute for Molecular Bioscience</wicri:noRegion></affiliation></author><author><name sortKey="Lopez Otin, Carlos" sort="Lopez Otin, Carlos" uniqKey="Lopez Otin C" first="Carlos" last="Lopez-Otin">Carlos Lopez-Otin</name><affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Departamento de Bioquimica y Biología Molecular, Facultad de Medicina, IUOPA, Universidad de Oviedo</s1><s2>Oviedo</s2><s3>ESP</s3><sZ>41 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J." last="Smyth">Mark J. Smyth</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne</s1><s2>Victoria</s2><s3>AUS</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Immunology, Monash University</s1><s2>Prahran, Victoria</s2><s3>AUS</s3><sZ>33 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Prahran, Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>INSERM, U1015</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>43 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>U1015</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>43 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507</wicri:noRegion><wicri:noRegion>Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507</wicri:noRegion></affiliation></author><author><name sortKey="Castedo, Maria" sort="Castedo, Maria" uniqKey="Castedo M" first="Maria" last="Castedo">Maria Castedo</name></author><author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Metabolomics Platform, Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>45 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="24"><s1>Centre de Recherche des Cordeliers</s1><s2>Paris</s2><s3>FRA</s3><sZ>45 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Pôle de Biologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris (AP-HP)</s1><s2>Paris</s2><s3>FRA</s3><sZ>45 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Science : (Washington, D.C.)</title><title level="j" type="abbreviated">Science : (Wash. D.C.)</title><idno type="ISSN">0036-8075</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Science : (Washington, D.C.)</title><title level="j" type="abbreviated">Science : (Wash. D.C.)</title><idno type="ISSN">0036-8075</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Cancer</term><term>Cancerology</term><term>Immunological surveillance</term><term>Malignant tumor</term><term>Mouse</term><term>Ploidy</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cancer</term><term>Cancérologie</term><term>Ploïdie</term><term>Tumeur maligne</term><term>Immunosurveillance</term><term>Souris</term><term>Animal</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Cancer</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cancer cells accommodate multiple genetic and epigenetic alterations that initially activate intrinsic (cell-autonomous) and extrinsic (immune-mediated) oncosuppressive mechanisms. Only once these barriers to oncogenesis have been overcome can malignant growth proceed unrestrained. Tetraploidization can contribute to oncogenesis because hyperploid cells are genomically unstable. We report that hyperploid cancer cells become immunogenic because of a constitutive endoplasmic reticulum stress response resulting in the aberrant cell surface exposure of calreticulin. Hyperploid, calreticulin-exposing cancer cells readily proliferated in immunodeficient mice and conserved their increased DNA content. In contrast, hyperploid cells injected into immunocompetent mice generated tumors only after a delay, and such tumors exhibited reduced DNA content, endoplasmic reticulum stress, and calreticulin exposure. Our results unveil an immunosurveillance system that imposes immunoselection against hyperploidy in carcinogen- and oncogene-induced cancers.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Autriche</li><li>Espagne</li><li>France</li><li>Italie</li></country><region><li>Bourgogne</li><li>Bourgogne-Franche-Comté</li><li>Latium</li><li>Victoria (État)</li><li>Vienne (Autriche)</li><li>Île-de-France</li></region><settlement><li>Dijon</li><li>Melbourne</li><li>Paris</li><li>Rome</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><noCountry><name sortKey="Castedo, Maria" sort="Castedo, Maria" uniqKey="Castedo M" first="Maria" last="Castedo">Maria Castedo</name><name sortKey="Talbot, Monique" sort="Talbot, Monique" uniqKey="Talbot M" first="Monique" last="Talbot">Monique Talbot</name></noCountry><country name="France"><noRegion><name sortKey="Senovilla, Laura" sort="Senovilla, Laura" uniqKey="Senovilla L" first="Laura" last="Senovilla">Laura Senovilla</name></noRegion><name sortKey="Adjemian, Sandy" sort="Adjemian, Sandy" uniqKey="Adjemian S" first="Sandy" last="Adjemian">Sandy Adjemian</name><name sortKey="Adjemian, Sandy" sort="Adjemian, Sandy" uniqKey="Adjemian S" first="Sandy" last="Adjemian">Sandy Adjemian</name><name sortKey="Adjemian, Sandy" sort="Adjemian, Sandy" uniqKey="Adjemian S" first="Sandy" last="Adjemian">Sandy Adjemian</name><name sortKey="Boileve, Alice" sort="Boileve, Alice" uniqKey="Boileve A" first="Alice" last="Boileve">Alice Boileve</name><name sortKey="Boileve, Alice" sort="Boileve, Alice" uniqKey="Boileve A" first="Alice" last="Boileve">Alice Boileve</name><name sortKey="Boileve, Alice" sort="Boileve, Alice" uniqKey="Boileve A" first="Alice" last="Boileve">Alice Boileve</name><name sortKey="Criollo, Alfredo" sort="Criollo, Alfredo" uniqKey="Criollo A" first="Alfredo" last="Criollo">Alfredo Criollo</name><name sortKey="Criollo, Alfredo" sort="Criollo, Alfredo" uniqKey="Criollo A" first="Alfredo" last="Criollo">Alfredo Criollo</name><name sortKey="Criollo, Alfredo" sort="Criollo, Alfredo" uniqKey="Criollo A" first="Alfredo" last="Criollo">Alfredo Criollo</name><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name><name sortKey="Ghiringhelli, Francois" sort="Ghiringhelli, Francois" uniqKey="Ghiringhelli F" first="François" last="Ghiringhelli">François Ghiringhelli</name><name sortKey="Ghiringhelli, Francois" sort="Ghiringhelli, Francois" uniqKey="Ghiringhelli F" first="François" last="Ghiringhelli">François Ghiringhelli</name><name sortKey="Job, Bastien" sort="Job, Bastien" uniqKey="Job B" first="Bastien" last="Job">Bastien Job</name><name sortKey="Job, Bastien" sort="Job, Bastien" uniqKey="Job B" first="Bastien" last="Job">Bastien Job</name><name sortKey="Job, Bastien" sort="Job, Bastien" uniqKey="Job B" first="Bastien" last="Job">Bastien Job</name><name sortKey="Kepp, Oliver" sort="Kepp, Oliver" uniqKey="Kepp O" first="Oliver" last="Kepp">Oliver Kepp</name><name sortKey="Kepp, Oliver" sort="Kepp, Oliver" uniqKey="Kepp O" first="Oliver" last="Kepp">Oliver Kepp</name><name sortKey="Kepp, Oliver" sort="Kepp, Oliver" uniqKey="Kepp O" first="Oliver" last="Kepp">Oliver Kepp</name><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><name sortKey="Ladoire, Sylvain" 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Smyth</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Sigl, Verena" sort="Sigl, Verena" uniqKey="Sigl V" first="Verena" last="Sigl">Verena Sigl</name></region><name sortKey="Carmona Gutierrez, Didac" sort="Carmona Gutierrez, Didac" uniqKey="Carmona Gutierrez D" first="Didac" last="Carmona-Gutierrez">Didac Carmona-Gutierrez</name><name sortKey="Madeo, Frank" sort="Madeo, Frank" uniqKey="Madeo F" first="Frank" last="Madeo">Frank Madeo</name><name sortKey="Penninger, Josef M" sort="Penninger, Josef M" uniqKey="Penninger J" first="Josef M." last="Penninger">Josef M. Penninger</name><name sortKey="Ruckenstuhl, Christoph" sort="Ruckenstuhl, Christoph" uniqKey="Ruckenstuhl C" first="Christoph" last="Ruckenstuhl">Christoph Ruckenstuhl</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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